Hydrochlorothiazide
Generic Name: Hydrochlorothiazide Common Brand Names: Microzide, HydroDIURIL, Esidrix Introduction Hydrochlorothiazide is a thiazide diuretic used to treat high blood pressure (hypertension) and edema (fluid retention). It works by promoting the excretion of sodium and water through the kidneys, leading to a reduction in blood volume and blood pressure. Conditions of Use (Indications) Hypertension: Used alone or in combination with other antihypertensive medications to lower blood pressure. Edema: Treats fluid retention associated with congestive heart failure, cirrhosis, and kidney disease. Nephrolithiasis: Off-label use to prevent the formation of calcium-containing kidney stones. Mechanism of Action Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidneys. This results in