Ketoconazole
Generic Name: Ketoconazole Common Brand Names: Nizoral, Extina, Xolegel Introduction Ketoconazole is an antifungal medication used to treat a variety of fungal infections, including those of the skin, nails, and systemic infections. It works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. Conditions of Use (Indications) Fungal Infections: Treatment of dermatophyte infections, candidiasis, and systemic fungal infections. Seborrheic Dermatitis: Used topically for managing seborrheic dermatitis and dandruff. Cushing’s Syndrome: Off-label use in managing endogenous Cushing’s syndrome by inhibiting cortisol synthesis. Mechanism of Action Ketoconazole inhibits the enzyme 14α-demethylase, which is involved in the synthesis of ergosterol, a critical component of the fungal cell membrane. By